Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4800581..4802262 Replicon chromosome
Accession NZ_CP110150
Organism Klebsiella pneumoniae strain YZ22CS072

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag OK018_RS23465 Protein ID WP_002885155.1
Coordinates 4800581..4801498 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A2L1C4M5
Locus tag OK018_RS23470 Protein ID WP_004192584.1
Coordinates 4801504..4802262 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OK018_RS23445 (4795887) 4795887..4797407 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
OK018_RS23450 (4797404) 4797404..4798402 + 999 WP_002885172.1 ribose ABC transporter permease -
OK018_RS23455 (4798433) 4798433..4799374 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
OK018_RS23460 (4799449) 4799449..4800456 + 1008 WP_004177805.1 carbohydrate kinase family protein -
OK018_RS23465 (4800581) 4800581..4801498 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OK018_RS23470 (4801504) 4801504..4802262 - 759 WP_004192584.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OK018_RS23475 (4802348) 4802348..4803076 - 729 WP_002885152.1 response regulator transcription factor -
OK018_RS23480 (4803349) 4803349..4805496 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
OK018_RS23485 (4805726) 4805726..4806412 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T263270 WP_002885155.1 NZ_CP110150:c4801498-4800581 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT263270 WP_004192584.1 NZ_CP110150:c4802262-4801504 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1C4M5

References