263256

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 288407..288929 Replicon plasmid unnamed1
Accession NZ_CP110149
Organism Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag OMA13_RS27215 Protein ID WP_004181778.1
Coordinates 288645..288929 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OMA13_RS27210 Protein ID WP_004181777.1
Coordinates 288407..288655 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMA13_RS27190 283616..284437 - 822 WP_004181772.1 hypothetical protein -
OMA13_RS27195 284499..284852 - 354 WP_004181774.1 hypothetical protein -
OMA13_RS27200 284997..285983 - 987 WP_094965947.1 hypothetical protein -
OMA13_RS27205 286317..288116 - 1800 WP_004181776.1 ATP-dependent helicase -
OMA13_RS27210 288407..288655 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OMA13_RS27215 288645..288929 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMA13_RS27220 288946..289047 - 102 Protein_326 IS200/IS605 family transposase -
OMA13_RS27225 289083..290309 + 1227 WP_040209639.1 RNA-guided endonuclease TnpB family protein -
OMA13_RS27230 290580..290804 - 225 Protein_328 transposase -
OMA13_RS27235 290883..291311 - 429 WP_077257669.1 IS200/IS605 family transposase -
OMA13_RS27240 291347..292534 + 1188 WP_040209642.1 RNA-guided endonuclease TnpB family protein -
OMA13_RS27245 292579..292950 - 372 WP_040209644.1 hypothetical protein -
OMA13_RS27250 292947..293291 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / aac(6')-Ib-cr / floR / aac(3)-IId / tet(D) / blaCTX-M-27 / qnrB52 / blaDHA-1 / qnrB4 - 1..368144 368144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T263256 WP_004181778.1 NZ_CP110149:288645-288929 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT263256 WP_004181777.1 NZ_CP110149:288407-288655 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References