Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5187668..5188293 Replicon chromosome
Accession NZ_CP110148
Organism Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OMA13_RS25205 Protein ID WP_002882817.1
Coordinates 5187668..5188051 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OMA13_RS25210 Protein ID WP_004150355.1
Coordinates 5188051..5188293 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMA13_RS25190 (5185034) 5185034..5185936 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OMA13_RS25195 (5185933) 5185933..5186568 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OMA13_RS25200 (5186565) 5186565..5187494 + 930 WP_115701461.1 formate dehydrogenase accessory protein FdhE -
OMA13_RS25205 (5187668) 5187668..5188051 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OMA13_RS25210 (5188051) 5188051..5188293 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OMA13_RS25215 (5188498) 5188498..5189415 + 918 WP_021466676.1 alpha/beta hydrolase -
OMA13_RS25220 (5189429) 5189429..5190370 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OMA13_RS25225 (5190415) 5190415..5190852 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OMA13_RS25230 (5190849) 5190849..5191709 - 861 WP_115701464.1 virulence factor BrkB family protein -
OMA13_RS25235 (5191703) 5191703..5192302 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T263253 WP_002882817.1 NZ_CP110148:c5188051-5187668 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263253 WP_004150355.1 NZ_CP110148:c5188293-5188051 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References