Detailed information of TA system TA263252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4869333..4871014
• Replicon: chromosome
• Accession: NZ_CP110148
• Organism: Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: OMA13_RS23735
• Protein ID: WP_004146663.1
• Coordinates: 4869333..4870250 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: OMA13_RS23740
• Protein ID: WP_004177809.1
• Coordinates: 4870256..4871014 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OMA13_RS23715 (4864639)	4864639..4866159	+	1521	WP_080845266.1	sugar ABC transporter ATP-binding protein	-
OMA13_RS23720 (4866156)	4866156..4867154	+	999	WP_004186549.1	ribose ABC transporter permease	-
OMA13_RS23725 (4867185)	4867185..4868126	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
OMA13_RS23730 (4868201)	4868201..4869208	+	1008	WP_032418187.1	carbohydrate kinase family protein	-
OMA13_RS23735 (4869333)	4869333..4870250	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OMA13_RS23740 (4870256)	4870256..4871014	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
OMA13_RS23745 (4871100)	4871100..4871828	-	729	WP_002885152.1	response regulator transcription factor	-
OMA13_RS23750 (4872101)	4872101..4874248	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
OMA13_RS23755 (4874478)	4874478..4875164	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T263252 WP_004146663.1 NZ_CP110148:c4870250-4869333 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT263252 WP_004177809.1 NZ_CP110148:c4871014-4870256 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05