Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4694579..4695095 Replicon chromosome
Accession NZ_CP110148
Organism Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag OMA13_RS22850 Protein ID WP_009486548.1
Coordinates 4694579..4694863 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag OMA13_RS22855 Protein ID WP_002886901.1
Coordinates 4694853..4695095 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMA13_RS22825 (4689996) 4689996..4690259 - 264 WP_031280360.1 PTS sugar transporter subunit IIB -
OMA13_RS22830 (4690389) 4690389..4690562 + 174 WP_032408826.1 hypothetical protein -
OMA13_RS22835 (4690565) 4690565..4691308 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OMA13_RS22840 (4691665) 4691665..4693803 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OMA13_RS22845 (4694111) 4694111..4694575 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OMA13_RS22850 (4694579) 4694579..4694863 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMA13_RS22855 (4694853) 4694853..4695095 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OMA13_RS22860 (4695173) 4695173..4697083 - 1911 WP_031593171.1 PRD domain-containing protein -
OMA13_RS22865 (4697106) 4697106..4698260 - 1155 WP_115701375.1 lactonase family protein -
OMA13_RS22870 (4698327) 4698327..4699067 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T263251 WP_009486548.1 NZ_CP110148:c4694863-4694579 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT263251 WP_002886901.1 NZ_CP110148:c4695095-4694853 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References