Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4594733..4595543 Replicon chromosome
Accession NZ_CP110148
Organism Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag OMA13_RS22425 Protein ID WP_002887280.1
Coordinates 4594733..4595266 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OMA13_RS22430 Protein ID WP_002887278.1
Coordinates 4595277..4595543 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMA13_RS22420 (4593564) 4593564..4594685 + 1122 WP_002887282.1 cupin domain-containing protein -
OMA13_RS22425 (4594733) 4594733..4595266 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
OMA13_RS22430 (4595277) 4595277..4595543 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OMA13_RS22435 (4595646) 4595646..4597079 - 1434 WP_115701576.1 Cu(+)/Ag(+) sensor histidine kinase -
OMA13_RS22440 (4597069) 4597069..4597752 - 684 WP_080893142.1 copper response regulator transcription factor CusR -
OMA13_RS22445 (4597925) 4597925..4599310 + 1386 WP_115701578.1 efflux transporter outer membrane subunit -
OMA13_RS22450 (4599328) 4599328..4599672 + 345 WP_021462623.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T263250 WP_002887280.1 NZ_CP110148:c4595266-4594733 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT263250 WP_002887278.1 NZ_CP110148:c4595543-4595277 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References