263248

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2630961..2632549 Replicon chromosome
Accession NZ_CP110148
Organism Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OMA13_RS12945 Protein ID WP_115700487.1
Coordinates 2630961..2632283 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OMA13_RS12950 Protein ID WP_004176198.1
Coordinates 2632283..2632549 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMA13_RS12930 (2626017) 2626017..2628518 + 2502 WP_115700490.1 fimbria/pilus outer membrane usher protein -
OMA13_RS12935 (2628506) 2628506..2629510 + 1005 WP_004224758.1 fimbrial protein -
OMA13_RS12940 (2629652) 2629652..2630944 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
OMA13_RS12945 (2630961) 2630961..2632283 - 1323 WP_115700487.1 type II toxin-antitoxin system HipA family toxin Toxin
OMA13_RS12950 (2632283) 2632283..2632549 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OMA13_RS12955 (2632814) 2632814..2633140 - 327 WP_021462560.1 hydroxyisourate hydrolase -
OMA13_RS12960 (2633137) 2633137..2633637 - 501 WP_080892840.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OMA13_RS12965 (2633615) 2633615..2634994 - 1380 WP_021462562.1 nucleobase:cation symporter-2 family protein -
OMA13_RS12970 (2635340) 2635340..2636494 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
OMA13_RS12975 (2636475) 2636475..2637398 - 924 WP_021462564.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49158.47 Da        Isoelectric Point: 7.5357

>T263248 WP_115700487.1 NZ_CP110148:c2632283-2630961 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQATGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT263248 WP_004176198.1 NZ_CP110148:c2632549-2632283 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References