Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 821478..822135 Replicon chromosome
Accession NZ_CP110148
Organism Klebsiella pneumoniae strain YZ22CS023

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OMA13_RS04145 Protein ID WP_002916310.1
Coordinates 821725..822135 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OMA13_RS04140 Protein ID WP_002916312.1
Coordinates 821478..821744 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMA13_RS04115 (816634) 816634..818067 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
OMA13_RS04120 (818186) 818186..818914 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
OMA13_RS04125 (818964) 818964..819275 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
OMA13_RS04130 (819439) 819439..820098 + 660 WP_002916317.1 hemolysin III family protein -
OMA13_RS04135 (820249) 820249..821232 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
OMA13_RS04140 (821478) 821478..821744 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OMA13_RS04145 (821725) 821725..822135 + 411 WP_002916310.1 protein YgfX Toxin
OMA13_RS04150 (822142) 822142..822663 - 522 WP_004144730.1 flavodoxin FldB -
OMA13_RS04155 (822764) 822764..823660 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
OMA13_RS04160 (823683) 823683..824396 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OMA13_RS04165 (824402) 824402..826135 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T263243 WP_002916310.1 NZ_CP110148:821725-822135 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT263243 WP_002916312.1 NZ_CP110148:821478-821744 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References