Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 168383..169293 Replicon plasmid unnamed2
Accession NZ_CP110147
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name - Uniprot ID R4YBC5
Locus tag OMD35_RS28170 Protein ID WP_004144067.1
Coordinates 168823..169293 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6A8PHD0
Locus tag OMD35_RS28165 Protein ID WP_023287184.1
Coordinates 168383..168826 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS28150 163682..164863 + 1182 WP_023287181.1 hypothetical protein -
OMD35_RS28155 164860..167088 + 2229 WP_032430744.1 ThiF family adenylyltransferase -
OMD35_RS28160 167141..168282 + 1142 Protein_164 translesion error-prone DNA polymerase V subunit UmuC -
OMD35_RS28165 168383..168826 + 444 WP_023287184.1 DUF2384 domain-containing protein Antitoxin
OMD35_RS28170 168823..169293 + 471 WP_004144067.1 RES family NAD+ phosphorylase Toxin
OMD35_RS28175 169380..169700 + 321 Protein_167 IS5/IS1182 family transposase -
OMD35_RS28180 169733..170701 + 969 WP_074423483.1 IS5 family transposase -
OMD35_RS28185 171040..172251 - 1212 WP_017901247.1 M24 family metallopeptidase -
OMD35_RS28190 172338..173291 - 954 WP_020481021.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aadA2 / dfrA12 / qnrS1 / blaLAP-2 / sul2 / aph(3')-Ia / mph(A) pla 1..216138 216138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17573.83 Da        Isoelectric Point: 4.5152

>T263240 WP_004144067.1 NZ_CP110147:168823-169293 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16522.84 Da        Isoelectric Point: 10.3013

>AT263240 WP_023287184.1 NZ_CP110147:168383-168826 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384IED8

Antitoxin

Source ID Structure
AlphaFold DB A0A6A8PHD0

References