Detailed information of TA system TA026324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3659519..3660198
• Replicon: chromosome
• Accession: NC_017171
• Organism: Acinetobacter baumannii MDR-ZJ06

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: ABZJ_RS17645
• Protein ID: WP_000838146.1
• Coordinates: 3660016..3660198 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: ABZJ_RS17640
• Protein ID: WP_000966688.1
• Coordinates: 3659519..3659923 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABZJ_RS17610	3656531..3657523	-	993	WP_000835645.1	KilA-N domain-containing protein	-
ABZJ_RS17615	3657520..3657675	-	156	WP_001103649.1	Arc family DNA-binding protein	-
ABZJ_RS17620	3657798..3658037	+	240	WP_000763623.1	Arc family DNA-binding protein	-
ABZJ_RS17625	3658086..3658880	-	795	WP_000720608.1	hypothetical protein	-
ABZJ_RS17630	3658912..3659235	-	324	WP_000523922.1	DUF4236 domain-containing protein	-
ABZJ_RS17635	3659244..3659420	-	177	WP_014466185.1	hypothetical protein	-
ABZJ_RS17640	3659519..3659923	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ABZJ_RS17645	3660016..3660198	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
ABZJ_RS17655	3660524..3661039	-	516	WP_001185608.1	hypothetical protein	-
ABZJ_RS17660	3661109..3662026	-	918	WP_000094250.1	hypothetical protein	-
ABZJ_RS17665	3662079..3663314	-	1236	WP_000002422.1	hypothetical protein	-
ABZJ_RS17670	3663314..3663667	-	354	WP_000064599.1	hypothetical protein	-
ABZJ_RS17675	3663761..3663979	-	219	WP_001277687.1	hypothetical protein	-
ABZJ_RS17680	3663981..3664379	-	399	WP_001251850.1	hypothetical protein	-
ABZJ_RS17685	3664381..3664749	-	369	WP_002055488.1	hypothetical protein	-
ABZJ_RS17690	3664721..3665125	-	405	WP_000247948.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T26324 WP_000838146.1 NC_017171:c3660198-3660016 [Acinetobacter baumannii MDR-ZJ06]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T26324 NC_017171:c3660198-3660016 [Acinetobacter baumannii MDR-ZJ06]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT26324 WP_000966688.1 NC_017171:c3659923-3659519 [Acinetobacter baumannii MDR-ZJ06]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT26324 NC_017171:c3659923-3659519 [Acinetobacter baumannii MDR-ZJ06]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6