Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 21558..22201 Replicon plasmid unnamed2
Accession NZ_CP110147
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name vagD Uniprot ID A0A155IU92
Locus tag OMD35_RS27460 Protein ID WP_000754567.1
Coordinates 21785..22201 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag OMD35_RS27455 Protein ID WP_001261275.1
Coordinates 21558..21788 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS27450 18729..21305 + 2577 WP_017901322.1 nuclease domain-containing protein -
OMD35_RS27455 21558..21788 + 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OMD35_RS27460 21785..22201 + 417 WP_000754567.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD35_RS27465 22382..23401 - 1020 WP_064160291.1 fimbrial protein -
OMD35_RS27470 23422..25815 - 2394 WP_064163930.1 fimbria/pilus outer membrane usher protein -
OMD35_RS27475 25827..26522 - 696 WP_064160295.1 molecular chaperone -
OMD35_RS27480 26581..27150 - 570 WP_064160296.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / aadA2 / dfrA12 / qnrS1 / blaLAP-2 / sul2 / aph(3')-Ia / mph(A) pla 1..216138 216138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15108.61 Da        Isoelectric Point: 8.5403

>T263238 WP_000754567.1 NZ_CP110147:21785-22201 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT263238 WP_001261275.1 NZ_CP110147:21558-21788 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A155IU92

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References