Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 47075..47985 Replicon plasmid unnamed1
Accession NZ_CP110146
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name - Uniprot ID A0A5Q9LR54
Locus tag OMD35_RS26140 Protein ID WP_004181896.1
Coordinates 47515..47985 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag OMD35_RS26135 Protein ID WP_004181895.1
Coordinates 47075..47518 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS26115 42427..42825 + 399 WP_004181717.1 H-NS family nucleoid-associated regulatory protein -
OMD35_RS26120 43710..45195 + 1486 Protein_43 group II intron reverse transcriptase/maturase -
OMD35_RS26125 45281..45703 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
OMD35_RS26130 45703..46974 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
OMD35_RS26135 47075..47518 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
OMD35_RS26140 47515..47985 + 471 WP_004181896.1 RES family NAD+ phosphorylase Toxin
OMD35_RS26145 48095..48355 - 261 WP_004026352.1 hypothetical protein -
OMD35_RS26150 49078..49236 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
OMD35_RS26155 49839..50813 + 975 WP_040222313.1 hypothetical protein -
OMD35_RS26160 51011..51388 - 378 WP_004181901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(6)-Id / aph(3'')-Ib / qnrB4 / blaDHA-1 / sul1 / armA / msr(E) / mph(E) / aph(3')-Ia / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 - 1..273252 273252
- inside Integron - - 137..273251 273114


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17549.81 Da        Isoelectric Point: 4.6155

>T263237 WP_004181896.1 NZ_CP110146:47515-47985 [Klebsiella pneumoniae]
VIFYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT263237 WP_004181895.1 NZ_CP110146:47075-47518 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LR54

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References