Detailed information of TA system TA263233

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4432915..4434596
• Replicon: chromosome
• Accession: NZ_CP110145
• Organism: Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: OMD35_RS21745
• Protein ID: WP_015959269.1
• Coordinates: 4432915..4433790 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: OMD35_RS21750
• Protein ID: WP_004177809.1
• Coordinates: 4433838..4434596 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OMD35_RS21725	4428221..4429741	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
OMD35_RS21730	4429738..4430736	+	999	WP_002885172.1	ribose ABC transporter permease	-
OMD35_RS21735	4430767..4431708	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
OMD35_RS21740	4431783..4432790	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
OMD35_RS21745	4432915..4433790	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
OMD35_RS21750	4433838..4434596	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
OMD35_RS21755	4434682..4435410	-	729	WP_032413197.1	response regulator transcription factor	-
OMD35_RS21760	4435683..4437830	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
OMD35_RS21765	4437827..4437970	-	144	WP_162897205.1	hypothetical protein	-
OMD35_RS21770	4438408..4439094	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T263233 WP_015959269.1 NZ_CP110145:c4433790-4432915 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT263233 WP_004177809.1 NZ_CP110145:c4434596-4433838 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05