Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4137639..4138449 Replicon chromosome
Accession NZ_CP110145
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag OMD35_RS20320 Protein ID WP_004178461.1
Coordinates 4137639..4138172 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag OMD35_RS20325 Protein ID WP_002887278.1
Coordinates 4138183..4138449 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS20315 4136470..4137591 + 1122 WP_064153030.1 cupin domain-containing protein -
OMD35_RS20320 4137639..4138172 - 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
OMD35_RS20325 4138183..4138449 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
OMD35_RS20330 4138552..4139985 - 1434 WP_009484674.1 Cu(+)/Ag(+) sensor histidine kinase -
OMD35_RS20335 4139975..4140658 - 684 WP_004214143.1 copper response regulator transcription factor CusR -
OMD35_RS20340 4140831..4142216 + 1386 WP_114263124.1 efflux transporter outer membrane subunit -
OMD35_RS20345 4142234..4142578 + 345 WP_032433444.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T263230 WP_004178461.1 NZ_CP110145:c4138172-4137639 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT263230 WP_002887278.1 NZ_CP110145:c4138449-4138183 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References