Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1031388..1032124 Replicon chromosome
Accession NZ_CP110145
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag OMD35_RS05120 Protein ID WP_032433360.1
Coordinates 1031642..1032124 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag OMD35_RS05115 Protein ID WP_003026799.1
Coordinates 1031388..1031654 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS05090 1027034..1028173 + 1140 WP_032433368.1 mannitol dehydrogenase -
OMD35_RS05095 1028202..1028864 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
OMD35_RS05100 1028845..1029852 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
OMD35_RS05105 1029870..1030502 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
OMD35_RS05110 1030512..1031075 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
OMD35_RS05115 1031388..1031654 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
OMD35_RS05120 1031642..1032124 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
OMD35_RS05125 1032485..1033084 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -
OMD35_RS05130 1033297..1034241 - 945 WP_077254249.1 fimbrial protein -
OMD35_RS05135 1034253..1034831 - 579 WP_032432061.1 type 1 fimbrial protein -
OMD35_RS05140 1034835..1035575 - 741 WP_050597964.1 molecular chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 999333..1043067 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T263223 WP_032433360.1 NZ_CP110145:1031642-1032124 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT263223 WP_003026799.1 NZ_CP110145:1031388-1031654 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References