Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1014697..1015340 Replicon chromosome
Accession NZ_CP110145
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag OMD35_RS05025 Protein ID WP_032433387.1
Coordinates 1014924..1015340 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag OMD35_RS05020 Protein ID WP_001261276.1
Coordinates 1014697..1014927 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS05005 1009719..1010806 + 1088 Protein_969 transcriptional repressor PifC -
OMD35_RS05010 1010809..1013049 + 2241 WP_045326788.1 P-loop NTPase fold protein -
OMD35_RS05015 1013577..1014392 - 816 WP_032433388.1 hypothetical protein -
OMD35_RS05020 1014697..1014927 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
OMD35_RS05025 1014924..1015340 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD35_RS05030 1015496..1016476 + 981 WP_032433385.1 hypothetical protein -
OMD35_RS05035 1016671..1018242 - 1572 WP_032433383.1 AAA family ATPase -
OMD35_RS05040 1018561..1018809 + 249 WP_032433382.1 hypothetical protein -
OMD35_RS05045 1018868..1019386 + 519 WP_045326794.1 hypothetical protein -
OMD35_RS05050 1019417..1019908 + 492 WP_032433378.1 hypothetical protein -
OMD35_RS05055 1019968..1020171 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 999333..1043067 43734


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T263222 WP_032433387.1 NZ_CP110145:1014924-1015340 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT263222 WP_001261276.1 NZ_CP110145:1014697-1014927 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References