Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 248247..249088 Replicon chromosome
Accession NZ_CP110145
Organism Klebsiella pneumoniae strain YZ22CK024

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1M0WJM1
Locus tag OMD35_RS01270 Protein ID WP_000854822.1
Coordinates 248705..249088 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M0CWL2
Locus tag OMD35_RS01265 Protein ID WP_053271974.1
Coordinates 248247..248615 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD35_RS01245 245992..246810 + 819 WP_001234702.1 DUF932 domain-containing protein -
OMD35_RS01250 246901..247386 + 486 WP_000214317.1 antirestriction protein -
OMD35_RS01255 247401..247877 + 477 WP_001186747.1 RadC family protein -
OMD35_RS01260 247946..248167 + 222 WP_000692312.1 DUF987 domain-containing protein -
OMD35_RS01265 248247..248615 + 369 WP_053271974.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OMD35_RS01270 248705..249088 + 384 WP_000854822.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
OMD35_RS01275 249079..249567 + 489 WP_001177592.1 DUF5983 family protein -
OMD35_RS01280 249534..249776 + 243 WP_166635458.1 DUF957 domain-containing protein -
OMD35_RS01285 249873..250718 + 846 WP_001280435.1 DUF4942 domain-containing protein -
OMD35_RS01295 251017..251523 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
OMD35_RS01300 251623..253464 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14295.32 Da        Isoelectric Point: 8.2830

>T263220 WP_000854822.1 NZ_CP110145:248705-249088 [Klebsiella pneumoniae]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Download         Length: 384 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13679.41 Da        Isoelectric Point: 6.4758

>AT263220 WP_053271974.1 NZ_CP110145:248247-248615 [Klebsiella pneumoniae]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M0WJM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0CWL2

References