263218

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 266360..266882 Replicon plasmid unnamed1
Accession NZ_CP110143
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name stbE Uniprot ID A0A0C7KG00
Locus tag OMD37_RS28305 Protein ID WP_038991638.1
Coordinates 266598..266882 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4R0U8
Locus tag OMD37_RS28300 Protein ID WP_004181777.1
Coordinates 266360..266608 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS28280 261569..262405 - 837 WP_014386523.1 hypothetical protein -
OMD37_RS28285 262452..262805 - 354 WP_004181774.1 hypothetical protein -
OMD37_RS28290 262950..263936 - 987 WP_086528942.1 hypothetical protein -
OMD37_RS28295 264270..266069 - 1800 WP_038991636.1 ATP-dependent helicase -
OMD37_RS28300 266360..266608 + 249 WP_004181777.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OMD37_RS28305 266598..266882 + 285 WP_038991638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD37_RS28310 267036..268262 + 1227 WP_229544130.1 transposase -
OMD37_RS28315 268534..268758 - 225 Protein_297 transposase -
OMD37_RS28320 268837..269265 - 429 WP_151373988.1 IS200/IS605 family transposase -
OMD37_RS28325 269301..270488 + 1188 WP_094284697.1 RNA-guided endonuclease TnpB family protein -
OMD37_RS28330 270533..270904 - 372 WP_227627908.1 hypothetical protein -
OMD37_RS28335 270901..271245 - 345 WP_223811496.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / blaDHA-1 / qnrB4 - 1..344396 344396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10993.73 Da        Isoelectric Point: 10.6516

>T263218 WP_038991638.1 NZ_CP110143:266598-266882 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYHLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8925.17 Da        Isoelectric Point: 3.8209

>AT263218 WP_004181777.1 NZ_CP110143:266360-266608 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGRIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7KG00

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4R0U8

References