Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 162760..163511 Replicon plasmid unnamed1
Accession NZ_CP110143
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag OMD37_RS27720 Protein ID WP_101826042.1
Coordinates 162760..163242 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6S4YWG5
Locus tag OMD37_RS27725 Protein ID WP_012540170.1
Coordinates 163233..163511 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS27690 157875..158569 - 695 Protein_172 zinc-binding dehydrogenase -
OMD37_RS27695 158653..159057 + 405 WP_285808051.1 transposase -
OMD37_RS27700 159054..159401 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
OMD37_RS27705 159450..160988 + 1539 WP_285808052.1 IS66-like element ISKpn24 family transposase -
OMD37_RS27710 161148..161981 - 834 WP_012540133.1 GIY-YIG nuclease family protein -
OMD37_RS27715 162318..162722 - 405 WP_048293664.1 DUF2251 domain-containing protein -
OMD37_RS27720 162760..163242 - 483 WP_101826042.1 GNAT family N-acetyltransferase Toxin
OMD37_RS27725 163233..163511 - 279 WP_012540170.1 DUF1778 domain-containing protein Antitoxin
OMD37_RS27730 163819..164355 + 537 WP_285808056.1 hypothetical protein -
OMD37_RS27735 165283..165741 - 459 WP_014386535.1 hypothetical protein -
OMD37_RS27740 166995..167879 + 885 WP_004186900.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / blaDHA-1 / qnrB4 - 1..344396 344396


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17698.59 Da        Isoelectric Point: 9.1776

>T263217 WP_101826042.1 NZ_CP110143:c163242-162760 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIADFCCQDQVLSEWLKKKALKNHSTGLSRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTEHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10749.33 Da        Isoelectric Point: 4.6722

>AT263217 WP_012540170.1 NZ_CP110143:c163511-163233 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFNAFVEELDAPMTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6S4YWG5

References