263216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 149617..150368 Replicon plasmid unnamed1
Accession NZ_CP110143
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name ataT Uniprot ID A0A071LQ79
Locus tag OMD37_RS27650 Protein ID WP_036114515.1
Coordinates 149886..150368 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag OMD37_RS27645 Protein ID WP_285808043.1
Coordinates 149617..149895 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS27620 145560..147149 - 1590 WP_285808037.1 IS66 family transposase -
OMD37_RS27625 147178..147528 - 351 WP_285808039.1 IS66 family insertion sequence element accessory protein TnpB -
OMD37_RS27630 148031..148771 + 741 WP_285808041.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
OMD37_RS27635 148858..149175 + 318 WP_285808064.1 hypothetical protein -
OMD37_RS27640 149283..149495 + 213 Protein_162 hypothetical protein -
OMD37_RS27645 149617..149895 + 279 WP_285808043.1 DUF1778 domain-containing protein Antitoxin
OMD37_RS27650 149886..150368 + 483 WP_036114515.1 GNAT family N-acetyltransferase Toxin
OMD37_RS27660 151399..153162 - 1764 WP_101984517.1 SgrR family transcriptional regulator -
OMD37_RS27665 153305..154129 + 825 WP_101984514.1 shikimate 5-dehydrogenase -
OMD37_RS27670 154224..155270 + 1047 Protein_168 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / blaDHA-1 / qnrB4 - 1..344396 344396
- inside IScluster/Tn - - 135355..150771 15416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(10-86)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17694.45 Da        Isoelectric Point: 8.9130

>T263216 WP_036114515.1 NZ_CP110143:149886-150368 [Klebsiella pneumoniae]
MGMRAPESLTSEHNIAEFCCQEPALNEWLKKKALRNHSTGISRVYVVCAENTNRVIGYYCLSSGSVHRNTVPGAYRRNAP
DVIPVIVLGRLAIDQAWSGNGLGAALLKDAIYRTQNIAFQVGVRALAVHALNEEVKCFYTRFGFEPSIVNTLTLLFPIKV

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10703.24 Da        Isoelectric Point: 4.6582

>AT263216 WP_285808043.1 NZ_CP110143:149617-149895 [Klebsiella pneumoniae]
MKPNVREAPINIRAKTSQRDLIDMAASLVSKSRTDFMLEVACREAQDILLDQRLFLLNDNQFEAFIEELDAPITPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A071LQ79

Antitoxin

Source ID Structure

References