Detailed information of TA system TA263215

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 50831..51741
• Replicon: plasmid unnamed1
• Accession: NZ_CP110143
• Organism: Klebsiella pneumoniae strain SBH193

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A663AYG0
• Locus tag: OMD37_RS27155
• Protein ID: WP_004026354.1
• Coordinates: 51271..51741 (+)
• Length: 157 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A2J4RLY9
• Locus tag: OMD37_RS27150
• Protein ID: WP_004181895.1
• Coordinates: 50831..51274 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OMD37_RS27120	46026..46454	+	429	WP_272734504.1	glutaredoxin-dependent arsenate reductase	-
OMD37_RS27125	46511..47188	-	678	WP_285808060.1	arsenical resistance protein ArsH	-
OMD37_RS27130	47230..47565	-	336	WP_115763904.1	metalloregulator ArsR/SmtB family transcription factor	-
OMD37_RS27135	47914..48363	+	450	WP_272734506.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
OMD37_RS27140	48372..49646	+	1275	WP_272734507.1	translesion error-prone DNA polymerase V subunit UmuC	-
OMD37_RS27145	49672..50730	+	1059	Protein_63	translesion error-prone DNA polymerase V subunit UmuC	-
OMD37_RS27150	50831..51274	+	444	WP_004181895.1	DUF2384 domain-containing protein	Antitoxin
OMD37_RS27155	51271..51741	+	471	WP_004026354.1	RES family NAD+ phosphorylase	Toxin
OMD37_RS27160	52196..52384	-	189	WP_088403065.1	hypothetical protein	-
OMD37_RS27165	52998..53258	-	261	WP_004026352.1	hypothetical protein	-
OMD37_RS27170	53972..54130	+	159	WP_004181898.1	type I toxin-antitoxin system Hok family toxin	-
OMD37_RS27175	54736..55710	+	975	WP_174232731.1	Hok/Gef family protein	-
OMD37_RS27180	55694..55816	+	123	WP_254911979.1	hypothetical protein	-
OMD37_RS27185	55908..56285	-	378	WP_029884711.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib / aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / qacE / aadA16 / dfrA27 / ARR-3 / blaDHA-1 / qnrB4	-	1..344396	344396

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 157 a.a.
• Molecular weight: 17515.79 Da
• Isoelectric Point: 4.6155

>T263215 WP_004026354.1 NZ_CP110143:51271-51741 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Nucleotide

• Length: 471 bp

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16536.87 Da
• Isoelectric Point: 10.3013

>AT263215 WP_004181895.1 NZ_CP110143:50831-51274 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Nucleotide

• Length: 444 bp

Structures

Toxin

• AlphaFold DB: A0A663AYG0

Antitoxin

• AlphaFold DB: A0A2J4RLY9