263214

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5387102..5387727 Replicon chromosome
Accession NZ_CP110142
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag OMD37_RS26465 Protein ID WP_002882817.1
Coordinates 5387102..5387485 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag OMD37_RS26470 Protein ID WP_004150355.1
Coordinates 5387485..5387727 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS26450 (5384468) 5384468..5385370 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
OMD37_RS26455 (5385367) 5385367..5386002 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
OMD37_RS26460 (5385999) 5385999..5386928 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
OMD37_RS26465 (5387102) 5387102..5387485 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD37_RS26470 (5387485) 5387485..5387727 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
OMD37_RS26475 (5387932) 5387932..5388849 + 918 WP_009484979.1 alpha/beta hydrolase -
OMD37_RS26480 (5388863) 5388863..5389804 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
OMD37_RS26485 (5389849) 5389849..5390286 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
OMD37_RS26490 (5390283) 5390283..5391143 - 861 WP_004146232.1 virulence factor BrkB family protein -
OMD37_RS26495 (5391137) 5391137..5391736 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T263214 WP_002882817.1 NZ_CP110142:c5387485-5387102 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT263214 WP_004150355.1 NZ_CP110142:c5387727-5387485 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References