263212

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4902673..4903189 Replicon chromosome
Accession NZ_CP110142
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag OMD37_RS24155 Protein ID WP_004178374.1
Coordinates 4902673..4902957 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A919M0P8
Locus tag OMD37_RS24160 Protein ID WP_032434351.1
Coordinates 4902947..4903189 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS24130 (4898156) 4898156..4898419 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
OMD37_RS24135 (4898549) 4898549..4898722 + 174 WP_032414379.1 hypothetical protein -
OMD37_RS24140 (4898725) 4898725..4899468 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
OMD37_RS24145 (4899825) 4899825..4901963 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
OMD37_RS24150 (4902205) 4902205..4902669 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
OMD37_RS24155 (4902673) 4902673..4902957 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OMD37_RS24160 (4902947) 4902947..4903189 - 243 WP_032434351.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
OMD37_RS24165 (4903267) 4903267..4905177 - 1911 Protein_4739 PRD domain-containing protein -
OMD37_RS24170 (4905200) 4905200..4906354 - 1155 WP_002886900.1 lactonase family protein -
OMD37_RS24175 (4906420) 4906420..4907160 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-68)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T263212 WP_004178374.1 NZ_CP110142:c4902957-4902673 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9003.47 Da        Isoelectric Point: 6.3340

>AT263212 WP_032434351.1 NZ_CP110142:c4903189-4902947 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGGKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure

References