Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4809945..4810648 Replicon chromosome
Accession NZ_CP110142
Organism Klebsiella pneumoniae strain SBH193

Toxin (Protein)


Gene name ykfI Uniprot ID A0A939NMR5
Locus tag OMD37_RS23760 Protein ID WP_071994632.1
Coordinates 4809945..4810286 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag OMD37_RS23765 Protein ID WP_032434296.1
Coordinates 4810307..4810648 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD37_RS23750 (4806260) 4806260..4807129 + 870 WP_023317468.1 HNH endonuclease -
OMD37_RS23755 (4807720) 4807720..4809753 + 2034 WP_050598589.1 hypothetical protein -
OMD37_RS23760 (4809945) 4809945..4810286 - 342 WP_071994632.1 TA system toxin CbtA family protein Toxin
OMD37_RS23765 (4810307) 4810307..4810648 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
OMD37_RS23770 (4810659) 4810659..4811201 - 543 WP_032434298.1 DNA repair protein RadC -
OMD37_RS23775 (4811214) 4811214..4811654 - 441 WP_032434300.1 antirestriction protein -
OMD37_RS23780 (4811685) 4811685..4812506 - 822 WP_032434301.1 DUF932 domain-containing protein -
OMD37_RS23785 (4812626) 4812626..4813099 - 474 WP_032434303.1 hypothetical protein -
OMD37_RS23790 (4813171) 4813171..4813623 - 453 WP_032410767.1 hypothetical protein -
OMD37_RS23795 (4813659) 4813659..4814375 - 717 WP_032434305.1 WYL domain-containing protein -
OMD37_RS23800 (4814619) 4814619..4815493 - 875 Protein_4667 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4798242..4843915 45673


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12789.77 Da        Isoelectric Point: 9.6552

>T263211 WP_071994632.1 NZ_CP110142:c4810286-4809945 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT263211 WP_032434296.1 NZ_CP110142:c4810648-4810307 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References