Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1942306..1942792 Replicon chromosome
Accession NZ_CP110141
Organism Streptococcus suis strain WUSS030

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag NOV96_RS09530 Protein ID WP_011922754.1
Coordinates 1942523..1942792 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag NOV96_RS09525 Protein ID WP_002938604.1
Coordinates 1942306..1942533 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV96_RS09500 (NOV96_09500) 1937638..1938183 - 546 WP_002938614.1 NADPH-dependent FMN reductase -
NOV96_RS09505 (NOV96_09505) 1938246..1938695 - 450 WP_002938613.1 MarR family transcriptional regulator -
NOV96_RS09510 (NOV96_09510) 1938998..1939495 + 498 WP_002938611.1 DUF5590 domain-containing protein -
NOV96_RS09515 (NOV96_09515) 1939492..1940673 + 1182 WP_002938610.1 pyridoxal phosphate-dependent aminotransferase -
NOV96_RS09520 (NOV96_09520) 1940688..1942034 + 1347 WP_013730302.1 asparagine--tRNA ligase -
NOV96_RS09525 (NOV96_09525) 1942306..1942533 + 228 WP_002938604.1 DUF6290 family protein Antitoxin
NOV96_RS09530 (NOV96_09530) 1942523..1942792 + 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOV96_RS09535 (NOV96_09535) 1943198..1943593 + 396 WP_044667951.1 MATE family efflux transporter -
NOV96_RS09540 (NOV96_09540) 1943662..1944951 + 1290 WP_002935134.1 IS4-like element ISSsu2 family transposase -
NOV96_RS09545 (NOV96_09545) 1945234..1947228 + 1995 WP_002935953.1 PTS system trehalose-specific EIIBC component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1943662..1944951 1289


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T263198 WP_011922754.1 NZ_CP110141:1942523-1942792 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT263198 WP_002938604.1 NZ_CP110141:1942306-1942533 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References