Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1293041..1294305 Replicon chromosome
Accession NZ_CP110141
Organism Streptococcus suis strain WUSS030

Toxin (Protein)


Gene name sezT Uniprot ID A0A8B2XHR8
Locus tag NOV96_RS06525 Protein ID WP_001235246.1
Coordinates 1293041..1293829 (-) Length 263 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A0Z8GXZ9
Locus tag NOV96_RS06530 Protein ID WP_024415699.1
Coordinates 1293829..1294305 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV96_RS06495 (NOV96_06495) 1288106..1288471 - 366 WP_000431640.1 MobC family plasmid mobilization relaxosome protein -
NOV96_RS06500 (NOV96_06500) 1288474..1288836 - 363 WP_024415701.1 SAG1252 family conjugative relaxosome accessory protein -
NOV96_RS06505 (NOV96_06505) 1289174..1289350 - 177 WP_001873137.1 hypothetical protein -
NOV96_RS06510 (NOV96_06510) 1289356..1289766 - 411 WP_001873139.1 hypothetical protein -
NOV96_RS06515 (NOV96_06515) 1289763..1291304 - 1542 WP_024415700.1 UvrD-helicase domain-containing protein -
NOV96_RS06520 (NOV96_06520) 1291297..1293051 - 1755 WP_000394601.1 AAA family ATPase -
NOV96_RS06525 (NOV96_06525) 1293041..1293829 - 789 WP_001235246.1 type II toxin-antitoxin system toxin PezT Toxin
NOV96_RS06530 (NOV96_06530) 1293829..1294305 - 477 WP_024415699.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
NOV96_RS06535 (NOV96_06535) 1294375..1294665 - 291 WP_000667953.1 hypothetical protein -
NOV96_RS06540 (NOV96_06540) 1294715..1295104 - 390 WP_024383484.1 DUF5945 family protein -
NOV96_RS06545 (NOV96_06545) 1295101..1295328 - 228 WP_024380481.1 DUF5965 family protein -
NOV96_RS06550 (NOV96_06550) 1295382..1296458 - 1077 WP_024415698.1 toprim domain-containing protein -
NOV96_RS06555 (NOV96_06555) 1296523..1298166 - 1644 WP_002935076.1 recombinase family protein -
NOV96_RS06560 (NOV96_06560) 1298292..1299188 + 897 WP_001809760.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) - 1227000..1341309 114309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(28-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 263 a.a.        Molecular weight: 29881.95 Da        Isoelectric Point: 6.5023

>T263197 WP_001235246.1 NZ_CP110141:c1293829-1293041 [Streptococcus suis]
MRLEEFSEVEFQKALQRTIRALTRGKTIPDQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSKRGYHLLIEGTLRTTQVPRQTAQLLTSKGYQVSLAIIGTKPELSYLSTLIRYEE
LYAIDPTQARATPKDHHDGIVENLVDNLRELEREQLFDQIQIYQRDRACIYDSETDEGSAAEVLQDCLFGKCSKVEEEMM
KLGRERLVKLNNKNLLESNYGI

Download         Length: 789 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18243.69 Da        Isoelectric Point: 4.4582

>AT263197 WP_024415699.1 NZ_CP110141:c1294305-1293829 [Streptococcus suis]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B2XHR8

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8GXZ9

References