263194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 772679..773162 Replicon chromosome
Accession NZ_CP110141
Organism Streptococcus suis strain WUSS030

Toxin (Protein)


Gene name relE Uniprot ID A0A0Z8BIZ7
Locus tag NOV96_RS03985 Protein ID WP_009910443.1
Coordinates 772902..773162 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0Z8BIX7
Locus tag NOV96_RS03980 Protein ID WP_012775256.1
Coordinates 772679..772900 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOV96_RS03950 (NOV96_03950) 767681..768316 + 636 WP_002935723.1 phosphoserine phosphatase SerB -
NOV96_RS03955 (NOV96_03955) 768347..768997 - 651 WP_002935722.1 HAD family hydrolase -
NOV96_RS03960 (NOV96_03960) 769105..770232 + 1128 WP_002935718.1 glycerate kinase -
NOV96_RS03965 (NOV96_03965) 770223..770450 + 228 WP_002935708.1 hypothetical protein -
NOV96_RS03970 (NOV96_03970) 770460..770912 - 453 WP_013730449.1 DUF1694 domain-containing protein -
NOV96_RS03975 (NOV96_03975) 771062..772369 + 1308 WP_002935704.1 phosphopyruvate hydratase -
NOV96_RS03980 (NOV96_03980) 772679..772900 + 222 WP_012775256.1 DUF6290 family protein Antitoxin
NOV96_RS03985 (NOV96_03985) 772902..773162 + 261 WP_009910443.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOV96_RS03990 (NOV96_03990) 773329..773970 + 642 WP_024413325.1 HAD family hydrolase -
NOV96_RS03995 (NOV96_03995) 774003..774188 - 186 WP_002935693.1 hypothetical protein -
NOV96_RS04000 (NOV96_04000) 774252..775256 - 1005 WP_024402853.1 lactonase family protein -
NOV96_RS04005 (NOV96_04005) 775392..776558 + 1167 WP_012775254.1 AI-2E family transporter -
NOV96_RS04010 (NOV96_04010) 776548..777777 + 1230 WP_044769950.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 700375..774188 73813


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10270.78 Da        Isoelectric Point: 9.6925

>T263194 WP_009910443.1 NZ_CP110141:772902-773162 [Streptococcus suis]
MYHLEYSKKAQKQIKKLDRQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKLVILALEFG
HRKDVY

Download         Length: 261 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8566.55 Da        Isoelectric Point: 4.4791

>AT263194 WP_012775256.1 NZ_CP110141:772679-772900 [Streptococcus suis]
MSTVTIRLNQEEEVFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYDEYKADPETISHADFKKELGL

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Z8BIZ7

Antitoxin

Source ID Structure
AlphaFold DB A0A0Z8BIX7

References