263187

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3739562..3740154 Replicon chromosome
Accession NZ_CP110131
Organism Methylorubrum extorquens strain NBC_00036

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag OKB92_RS18075 Protein ID WP_265221661.1
Coordinates 3739562..3739864 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag OKB92_RS18080 Protein ID WP_265221662.1
Coordinates 3739861..3740154 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKB92_RS18050 (OKB92_18050) 3735109..3735747 - 639 WP_265221657.1 L,D-transpeptidase -
OKB92_RS18055 (OKB92_18055) 3735746..3735994 + 249 WP_265221658.1 hypothetical protein -
OKB92_RS18060 (OKB92_18060) 3736126..3736977 + 852 WP_265221659.1 histone deacetylase family protein -
OKB92_RS18065 (OKB92_18065) 3737132..3738211 - 1080 WP_015823256.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
OKB92_RS18070 (OKB92_18070) 3738340..3739440 - 1101 WP_265221660.1 chorismate synthase -
OKB92_RS18075 (OKB92_18075) 3739562..3739864 + 303 WP_265221661.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OKB92_RS18080 (OKB92_18080) 3739861..3740154 + 294 WP_265221662.1 putative addiction module antidote protein Antitoxin
OKB92_RS18085 (OKB92_18085) 3740148..3740771 - 624 WP_265221663.1 DUF3578 domain-containing protein -
OKB92_RS18090 (OKB92_18090) 3740768..3741901 - 1134 WP_265221664.1 anhydro-N-acetylmuramic acid kinase -
OKB92_RS18095 (OKB92_18095) 3742042..3743313 + 1272 WP_265221665.1 tyrosine--tRNA ligase -
OKB92_RS18100 (OKB92_18100) 3743383..3744330 - 948 WP_238506802.1 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Uncharacterized protein HI1420

(2-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11129.87 Da        Isoelectric Point: 10.2636

>T263187 WP_265221661.1 NZ_CP110131:3739562-3739864 [Methylorubrum extorquens]
MLEIIRTRTFADWLKGLRDDRAKARIALRIDRLALGHEGDSKAVGGGVSELRIDYGPGYRIYFTYRGKTLVVLLCGGDKA
SQKRDISRAKTLATMLDGTE

Download         Length: 303 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10378.56 Da        Isoelectric Point: 4.2220

>AT263187 WP_265221662.1 NZ_CP110131:3739861-3740154 [Methylorubrum extorquens]
MMTETSPYDSAEFLESDEAVAEYLAAAIEEGDAALFRRALGVAARARGMTQIARETGLSRESLYRALSDDGNPSLDTALR
VLNALNVRLTASVASPQ

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References