Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5410751..5411333 Replicon chromosome
Accession NZ_CP110130
Organism Methylorubrum extorquens strain NBC_00404

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag OKC48_RS25620 Protein ID WP_012252142.1
Coordinates 5411058..5411333 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID H1KK02
Locus tag OKC48_RS25615 Protein ID WP_003600760.1
Coordinates 5410751..5411068 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKC48_RS25600 (OKC48_25600) 5406023..5406997 - 975 WP_265223400.1 aliphatic sulfonate ABC transporter substrate-binding protein -
OKC48_RS25605 (OKC48_25605) 5407157..5409943 + 2787 WP_265223399.1 [protein-PII] uridylyltransferase -
OKC48_RS25610 (OKC48_25610) 5410035..5410643 + 609 WP_003600761.1 nucleotide exchange factor GrpE -
OKC48_RS25615 (OKC48_25615) 5410751..5411068 - 318 WP_003600760.1 BrnA antitoxin family protein Antitoxin
OKC48_RS25620 (OKC48_25620) 5411058..5411333 - 276 WP_012252142.1 BrnT family toxin Toxin
OKC48_RS25625 (OKC48_25625) 5411425..5412282 - 858 WP_265223397.1 prephenate dehydratase -
OKC48_RS25630 (OKC48_25630) 5412299..5413042 - 744 WP_265223396.1 3-deoxy-manno-octulosonate cytidylyltransferase -
OKC48_RS25635 (OKC48_25635) 5413350..5414267 + 918 WP_265244735.1 c-type cytochrome -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-84)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-100)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10017.51 Da        Isoelectric Point: 7.0130

>T263184 WP_012252142.1 NZ_CP110130:c5411333-5411058 [Methylorubrum extorquens]
MLIVWDEPKRLTNLQKHGLDFADFEAGFDFETALVAVAQPSAAGSARMKIIGEFDGQTVVAAIIAPLGREAISLISLRRA
SRSERRLYDAR

Download         Length: 276 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11641.04 Da        Isoelectric Point: 5.1832

>AT263184 WP_003600760.1 NZ_CP110130:c5411068-5410751 [Methylorubrum extorquens]
MPADKPDRRPTTTSEEAGIQAGIAADPDNPEWTEADFRSAVPFEQAFPVLAEKLRRTRGPQSAPTKQLVSLRLDQDVLLR
FRATGPGWQSRMNEALRRAAADLPD

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H1KK02

References