Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 3299192..3300197 Replicon chromosome
Accession NZ_CP110127
Organism Mycolicibacterium fortuitum strain ATCC 35855

Toxin (Protein)


Gene name pezT Uniprot ID K0VF36
Locus tag OMF10_RS15900 Protein ID WP_003884794.1
Coordinates 3299619..3300197 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID K0VQA4
Locus tag OMF10_RS15895 Protein ID WP_003884795.1
Coordinates 3299192..3299581 (+) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMF10_RS15875 (OMF10_15900) 3295201..3295749 - 549 WP_003884799.1 GNAT family N-acetyltransferase -
OMF10_RS15880 (OMF10_15905) 3295781..3296191 - 411 WP_003884798.1 transglycosylase family protein -
OMF10_RS15885 (OMF10_15910) 3296586..3297944 - 1359 WP_003884797.1 alpha/beta hydrolase-fold protein -
OMF10_RS15890 (OMF10_15915) 3298108..3299130 + 1023 WP_003884796.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
OMF10_RS15895 (OMF10_15920) 3299192..3299581 + 390 WP_003884795.1 hypothetical protein Antitoxin
OMF10_RS15900 (OMF10_15925) 3299619..3300197 + 579 WP_003884794.1 zeta toxin family protein Toxin
OMF10_RS15905 (OMF10_15930) 3300269..3300652 + 384 WP_144402881.1 hypothetical protein -
OMF10_RS15910 (OMF10_15935) 3300672..3301307 - 636 WP_003884793.1 histidine phosphatase family protein -
OMF10_RS15915 (OMF10_15940) 3301343..3301699 - 357 WP_003884792.1 hypothetical protein -
OMF10_RS15920 (OMF10_15945) 3301710..3302435 - 726 WP_003884791.1 thiocyanate hydrolase subunit gamma -
OMF10_RS15925 (OMF10_15950) 3302470..3303294 - 825 WP_003884790.1 nitrile hydratase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21036.14 Da        Isoelectric Point: 8.5146

>T263171 WP_003884794.1 NZ_CP110127:3299619-3300197 [Mycolicibacterium fortuitum]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKHRWPQDPASHSYEAALVAAETRAKLIQLGESFIAETVFSH
PSKLELIDDARAAGYTLILHCLLIPEELAVQRVRHRVRAGGHHVPEKKIRERYQRLWDLVAIAAIRVDSATFYDNSAVSG
PRIVAQIVGGFVVGSPTWPTWTPTALSSRWPG

Download         Length: 579 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13567.00 Da        Isoelectric Point: 4.5256

>AT263171 WP_003884795.1 NZ_CP110127:3299192-3299581 [Mycolicibacterium fortuitum]
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIALGELTAEEGAVFDAEI
AASIEESLARTDYGKALAARGITTVALDEDGEIVQYLPDGSTAVLAPQQ

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0VF36

Antitoxin

Source ID Structure
AlphaFold DB K0VQA4

References