263170

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1350095..1350727 Replicon chromosome
Accession NZ_CP110127
Organism Mycolicibacterium fortuitum strain ATCC 35855

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag OMF10_RS06350 Protein ID WP_003881879.1
Coordinates 1350278..1350727 (+) Length 150 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID K0VFT5
Locus tag OMF10_RS06345 Protein ID WP_003881878.1
Coordinates 1350095..1350274 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMF10_RS06330 (OMF10_06340) 1345634..1346368 + 735 WP_003881875.1 enoyl-CoA hydratase -
OMF10_RS06335 (OMF10_06345) 1346370..1347476 + 1107 WP_003881876.1 MBL fold metallo-hydrolase -
OMF10_RS06340 (OMF10_06350) 1347543..1350035 + 2493 WP_038563367.1 cation-translocating P-type ATPase -
OMF10_RS06345 (OMF10_06355) 1350095..1350274 + 180 WP_003881878.1 antitoxin Antitoxin
OMF10_RS06350 (OMF10_06360) 1350278..1350727 + 450 WP_003881879.1 SRPBCC family protein Toxin
OMF10_RS06355 (OMF10_06365) 1350731..1351159 - 429 WP_003881880.1 hypothetical protein -
OMF10_RS06360 (OMF10_06370) 1351179..1351880 - 702 WP_003881881.1 hypothetical protein -
OMF10_RS06365 (OMF10_06375) 1351877..1352008 - 132 WP_003881882.1 hypothetical protein -
OMF10_RS06370 (OMF10_06380) 1352024..1352824 - 801 WP_003881883.1 CbbQ/NirQ/NorQ/GpvN family protein -
OMF10_RS06375 (OMF10_06385) 1352821..1354350 - 1530 WP_003881884.1 VWA domain-containing protein -
OMF10_RS06380 (OMF10_06390) 1354502..1355104 - 603 WP_003881886.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 150 a.a.        Molecular weight: 16117.67 Da        Isoelectric Point: 9.6573

>T263170 WP_003881879.1 NZ_CP110127:1350278-1350727 [Mycolicibacterium fortuitum]
MAKLSVSVEVPLPPEKAWEYASDLSRYDEWLSIHRAWRSKLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPQSLTLN
GDGRGGVKVKLIGKITPAAVDGGDGAKVSFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKELYASS

Download         Length: 450 bp

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6434.15 Da        Isoelectric Point: 4.5045

>AT263170 WP_003881878.1 NZ_CP110127:1350095-1350274 [Mycolicibacterium fortuitum]
MGFLDKAKDLLSQNADKVEQAIEKAGDIVDEKTQGKYSGVVDKAQEAAKNAINKEEPQQ

Download         Length: 180 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB K0VFT5

References