Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4706922..4707741 Replicon chromosome
Accession NZ_CP110123
Organism Klebsiella michiganensis strain MX581

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag OKE89_RS22860 Protein ID WP_004110819.1
Coordinates 4707484..4707741 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID A0A7H5A4B4
Locus tag OKE89_RS22855 Protein ID WP_004847994.1
Coordinates 4706922..4707473 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKE89_RS22835 (OKE89_22830) 4702313..4703710 + 1398 WP_004848000.1 MFS transporter -
OKE89_RS22840 (OKE89_22835) 4703833..4705173 + 1341 WP_004847998.1 carbohydrate porin -
OKE89_RS22845 (OKE89_22840) 4705276..4706022 - 747 WP_223226651.1 class I SAM-dependent methyltransferase -
OKE89_RS22850 (OKE89_22845) 4706446..4706808 - 363 Protein_4488 class I SAM-dependent methyltransferase -
OKE89_RS22855 (OKE89_22850) 4706922..4707473 - 552 WP_004847994.1 N-acetyltransferase Antitoxin
OKE89_RS22860 (OKE89_22855) 4707484..4707741 - 258 WP_004110819.1 YjhX family toxin Toxin
OKE89_RS22865 (OKE89_22860) 4708417..4709601 + 1185 WP_049105906.1 mannonate dehydratase -
OKE89_RS22870 (OKE89_22865) 4709675..4711150 + 1476 WP_049105907.1 fructuronate reductase -
OKE89_RS22875 (OKE89_22870) 4711289..4712065 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T263167 WP_004110819.1 NZ_CP110123:c4707741-4707484 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20022.86 Da        Isoelectric Point: 6.4897

>AT263167 WP_004847994.1 NZ_CP110123:c4707473-4706922 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGGLIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A7H5A4B4

References