Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874652..875309 Replicon chromosome
Accession NZ_CP110123
Organism Klebsiella michiganensis strain MX581

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag OKE89_RS04255 Protein ID WP_004854060.1
Coordinates 874899..875309 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag OKE89_RS04250 Protein ID WP_004124953.1
Coordinates 874652..874918 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKE89_RS04235 (OKE89_04235) 869904..870329 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
OKE89_RS04240 (OKE89_04240) 870450..873248 - 2799 WP_264604054.1 transcriptional regulator DagR -
OKE89_RS04245 (OKE89_04245) 873424..874407 - 984 WP_004854063.1 tRNA-modifying protein YgfZ -
OKE89_RS04250 (OKE89_04250) 874652..874918 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
OKE89_RS04255 (OKE89_04255) 874899..875309 + 411 WP_004854060.1 protein YgfX Toxin
OKE89_RS04260 (OKE89_04260) 875318..875839 - 522 WP_004854059.1 flavodoxin FldB -
OKE89_RS04265 (OKE89_04265) 875961..876857 + 897 WP_004854056.1 site-specific tyrosine recombinase XerD -
OKE89_RS04270 (OKE89_04270) 876880..877593 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OKE89_RS04275 (OKE89_04275) 877599..879332 + 1734 WP_004854053.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T263159 WP_004854060.1 NZ_CP110123:874899-875309 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT263159 WP_004124953.1 NZ_CP110123:874652-874918 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References