Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 78063..78688 Replicon plasmid p2-331_1
Accession NZ_CP110118
Organism Escherichia coli strain 2-331

Toxin (Protein)


Gene name vapC Uniprot ID A0A1D7QA53
Locus tag OMD12_RS24605 Protein ID WP_039023147.1
Coordinates 78290..78688 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1D7QA08
Locus tag OMD12_RS24600 Protein ID WP_039023146.1
Coordinates 78063..78290 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD12_RS24600 (78063) 78063..78290 + 228 WP_039023146.1 toxin-antitoxin system antitoxin VapB Antitoxin
OMD12_RS24605 (78290) 78290..78688 + 399 WP_039023147.1 type II toxin-antitoxin system VapC family toxin Toxin
OMD12_RS24610 (78697) 78697..80895 - 2199 WP_061856952.1 type IV conjugative transfer system coupling protein TraD -
OMD12_RS24615 (81148) 81148..81879 - 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
OMD12_RS24620 (81911) 81911..82408 - 498 WP_000605862.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid mph(A) / blaTEM-1B / rmtB / blaNDM-6 / sul1 / qacE / aadA2 / dfrA12 / tet(A) - 1..143596 143596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14885.26 Da        Isoelectric Point: 8.2824

>T263149 WP_039023147.1 NZ_CP110118:78290-78688 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAAIHT
GQIRAELARQGRPVGPFDQMIAGHARCRGLIIVTNNTREFERVGGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8549.62 Da        Isoelectric Point: 4.7513

>AT263149 WP_039023146.1 NZ_CP110118:78063-78290 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPENVKRVEVIAIGRTRLITPAGETWDEWFDGHSVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7QA53

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7QA08

References