Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3641632..3642250 Replicon chromosome
Accession NZ_CP110117
Organism Escherichia coli strain 2-331

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag OMD12_RS17855 Protein ID WP_001291435.1
Coordinates 3642032..3642250 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag OMD12_RS17850 Protein ID WP_000344800.1
Coordinates 3641632..3642006 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OMD12_RS17840 (3636721) 3636721..3637914 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OMD12_RS17845 (3637937) 3637937..3641086 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
OMD12_RS17850 (3641632) 3641632..3642006 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
OMD12_RS17855 (3642032) 3642032..3642250 + 219 WP_001291435.1 HHA domain-containing protein Toxin
OMD12_RS17860 (3642422) 3642422..3642973 + 552 WP_000102564.1 maltose O-acetyltransferase -
OMD12_RS17865 (3643089) 3643089..3643559 + 471 WP_000136192.1 YlaC family protein -
OMD12_RS17870 (3643723) 3643723..3645273 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
OMD12_RS17875 (3645315) 3645315..3645668 - 354 WP_000878140.1 DUF1428 domain-containing protein -
OMD12_RS17885 (3646047) 3646047..3646358 + 312 WP_000409911.1 MGMT family protein -
OMD12_RS17890 (3646389) 3646389..3646961 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T263141 WP_001291435.1 NZ_CP110117:3642032-3642250 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT263141 WP_000344800.1 NZ_CP110117:3641632-3642006 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References