Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 3595627..3596273 Replicon chromosome
Accession NC_017168
Organism Yersinia pestis A1122

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag A1122_RS16875 Protein ID WP_002214976.1
Coordinates 3595627..3595809 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag A1122_RS16880 Protein ID WP_002211129.1
Coordinates 3595854..3596273 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A1122_RS16840 3591013..3591483 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
A1122_RS16845 3591489..3592490 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
A1122_RS16850 3592487..3592903 + 417 WP_002211134.1 flagellar motor switch protein FliN -
A1122_RS16855 3592903..3593439 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
A1122_RS16860 3593520..3594260 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
A1122_RS16865 3594366..3594635 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
A1122_RS16870 3594638..3595420 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
A1122_RS16875 3595627..3595809 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
A1122_RS16880 3595854..3596273 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
A1122_RS16885 3596531..3597490 - 960 WP_002211128.1 sugar kinase -
A1122_RS16890 3597539..3598561 - 1023 WP_002214974.1 ABC transporter permease -
A1122_RS16895 3598564..3600141 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
A1122_RS16900 3600207..3601202 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T26314 WP_002214976.1 NC_017168:3595627-3595809 [Yersinia pestis A1122]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T26314 NC_017168:3595627-3595809 [Yersinia pestis A1122]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT26314 WP_002211129.1 NC_017168:3595854-3596273 [Yersinia pestis A1122]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT26314 NC_017168:3595854-3596273 [Yersinia pestis A1122]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References