Detailed information of TA system TA026313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 3121698..3122664
• Replicon: chromosome
• Accession: NC_017168
• Organism: Yersinia pestis A1122

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: A1122_RS14505
• Protein ID: WP_002210981.1
• Coordinates: 3121698..3122156 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: Q66A69
• Locus tag: A1122_RS14510
• Protein ID: WP_002210982.1
• Coordinates: 3122218..3122664 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A1122_RS14475	3117512..3118177	+	666	WP_002210975.1	phage shock protein PspA	-
A1122_RS14480	3118339..3118566	+	228	WP_002210976.1	envelope stress response membrane protein PspB	-
A1122_RS14485	3118566..3118925	+	360	WP_002210977.1	envelope stress response membrane protein PspC	-
A1122_RS14490	3119010..3119252	+	243	WP_002216375.1	phage shock protein PspD	-
A1122_RS14495	3119233..3120630	+	1398	WP_002210979.1	YcjX family protein	-
A1122_RS14500	3120627..3121688	+	1062	WP_002210980.1	YcjF family protein	-
A1122_RS14505	3121698..3122156	-	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
A1122_RS14510	3122218..3122664	-	447	WP_002210982.1	DUF2384 domain-containing protein	Antitoxin
A1122_RS14515	3122999..3124576	+	1578	WP_002210983.1	transcriptional regulator TyrR	-
A1122_RS14520	3124723..3125181	-	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
A1122_RS14525	3125434..3125937	-	504	WP_002210984.1	thiol peroxidase	-
A1122_RS14530	3126100..3127074	+	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3124723..3125181	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre (15-147)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T26313 WP_002210981.1 NC_017168:c3122156-3121698 [Yersinia pestis A1122]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T26313 NC_017168:c3122156-3121698 [Yersinia pestis A1122]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16401.94 Da
• Isoelectric Point: 9.7155

>AT26313 WP_002210982.1 NC_017168:c3122664-3122218 [Yersinia pestis A1122]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT26313 NC_017168:c3122664-3122218 [Yersinia pestis A1122]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E8XFL1