Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 3720467..3721109 Replicon chromosome
Accession NZ_CP110109
Organism Bacillus thuringiensis strain TG-5

Toxin (Protein)


Gene name pemK Uniprot ID R8I8B8
Locus tag OKV75_RS19060 Protein ID WP_000635965.1
Coordinates 3720759..3721109 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag OKV75_RS19055 Protein ID WP_000004570.1
Coordinates 3720467..3720754 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKV75_RS19030 3715784..3716746 + 963 WP_000961144.1 UV DNA damage repair endonuclease UvsE -
OKV75_RS19035 3716739..3717311 - 573 WP_000908526.1 rhomboid family intramembrane serine protease -
OKV75_RS19040 3717405..3717764 + 360 WP_071713817.1 holo-ACP synthase -
OKV75_RS19045 3717921..3718871 + 951 WP_002094231.1 outer membrane lipoprotein carrier protein LolA -
OKV75_RS19050 3718989..3720158 + 1170 WP_000390593.1 alanine racemase -
OKV75_RS19055 3720467..3720754 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
OKV75_RS19060 3720759..3721109 + 351 WP_000635965.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
OKV75_RS19065 3721178..3723346 + 2169 WP_071713819.1 Tex family protein -
OKV75_RS19070 3723404..3723520 - 117 WP_001143640.1 cortex morphogenetic protein CmpA -
OKV75_RS19075 3723716..3724174 + 459 WP_071713820.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12948.04 Da        Isoelectric Point: 5.7168

>T263122 WP_000635965.1 NZ_CP110109:3720759-3721109 [Bacillus thuringiensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMSRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT263122 WP_000004570.1 NZ_CP110109:3720467-3720754 [Bacillus thuringiensis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A366G118

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References