Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 463508..464486 Replicon chromosome
Accession NZ_CP110109
Organism Bacillus thuringiensis strain TG-5

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag OKV75_RS02510 Protein ID WP_072938428.1
Coordinates 463508..464245 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag OKV75_RS02515 Protein ID WP_000237818.1
Coordinates 464358..464486 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OKV75_RS02485 459123..459530 + 408 WP_000072492.1 VOC family protein -
OKV75_RS02490 459543..459932 + 390 Protein_497 SAM-dependent methyltransferase -
OKV75_RS02495 460090..461766 - 1677 WP_000745300.1 alpha-keto acid decarboxylase family protein -
OKV75_RS02500 461883..462365 + 483 WP_072938422.1 MarR family winged helix-turn-helix transcriptional regulator -
OKV75_RS02505 462532..463269 + 738 WP_072938425.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
OKV75_RS02510 463508..464245 + 738 WP_072938428.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
OKV75_RS02515 464358..464486 + 129 WP_000237818.1 hypothetical protein Antitoxin
OKV75_RS02520 464559..464735 + 177 WP_000852629.1 stage II sporulation protein SB -
OKV75_RS02525 464755..465144 - 390 WP_098398982.1 YxeA family protein -
OKV75_RS02530 465356..466825 + 1470 WP_071714840.1 beta-Ala-His dipeptidase -
OKV75_RS02535 467071..467880 + 810 WP_000664543.1 papain-like cysteine protease family protein -
OKV75_RS02540 467906..468508 + 603 WP_098919627.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 407835..477710 69875


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28364.13 Da        Isoelectric Point: 9.0291

>T263121 WP_072938428.1 NZ_CP110109:463508-464245 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPSVFGKMEWHTEEEYTKSLNAFLDSYAEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT263121 WP_000237818.1 NZ_CP110109:464358-464486 [Bacillus thuringiensis]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References