Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 205311..205935 Replicon chromosome
Accession NZ_CP110087
Organism Moraxella bovis strain SAM109242

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LP095_RS01090 Protein ID WP_264677651.1
Coordinates 205311..205613 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LP095_RS01095 Protein ID WP_264677652.1
Coordinates 205600..205935 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP095_RS01065 (LP095_01065) 200405..200959 + 555 WP_078274416.1 porin family protein -
LP095_RS01070 (LP095_01070) 201216..202571 - 1356 WP_272506296.1 FAD-dependent oxidoreductase -
LP095_RS01080 (LP095_01080) 202590..203708 - 1119 WP_264677649.1 acyl-CoA dehydrogenase family protein -
LP095_RS01085 (LP095_01085) 203818..205173 - 1356 WP_264677650.1 anthranilate synthase component I family protein -
LP095_RS01090 (LP095_01090) 205311..205613 + 303 WP_264677651.1 type II toxin-antitoxin system HicA family toxin Toxin
LP095_RS01095 (LP095_01095) 205600..205935 + 336 WP_264677652.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LP095_RS01100 (LP095_01100) 205968..206432 - 465 WP_264677653.1 hypothetical protein -
LP095_RS01105 (LP095_01105) 206620..207852 - 1233 WP_264677654.1 beta-ketoacyl-ACP synthase II -
LP095_RS01110 (LP095_01110) 208027..208767 - 741 WP_112742704.1 single-stranded DNA-binding protein -
LP095_RS01115 (LP095_01115) 209227..209544 - 318 WP_078274423.1 H-NS histone family protein -
LP095_RS01120 (LP095_01120) 209753..210823 - 1071 WP_115368772.1 5'-nucleotidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(21-73)

Antitoxin

Uncharacterised protein family HicB

(52-100)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11427.89 Da        Isoelectric Point: 6.3267

>T263097 WP_264677651.1 NZ_CP110087:205311-205613 [Moraxella bovis]
MTKSDKLKAKLYGDVRTFVFSDLVTLLSQLGYEMHERAGSRVVFVHCDDNSDRIHLHKPHPENTIKGGALKAVKAYLSEK
GYFDEFNDDVLNQELKNDDL

Download         Length: 303 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12590.10 Da        Isoelectric Point: 4.4118

>AT263097 WP_264677652.1 NZ_CP110087:205600-205935 [Moraxella bovis]
MMTYKGYVGEFTLDNDDEIFYGKLIGINQLVTFEADNAHDLKQAFYDSVDDYLAFCAEQGIEPDKPFKGSFNVRIDSELH
RRAYMASRDSSLNAFVGQAISEKLNRMAVSI

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References