Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3605577..3606199 Replicon chromosome
Accession NZ_CP110080
Organism Buttiauxella sp. WJP83

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag OH773_RS16670 Protein ID WP_121265420.1
Coordinates 3605981..3606199 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1B7HUH8
Locus tag OH773_RS16665 Protein ID WP_034458068.1
Coordinates 3605577..3605951 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH773_RS16655 (OH773_16655) 3600655..3601854 + 1200 WP_270140154.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OH773_RS16660 (OH773_16660) 3601877..3605026 + 3150 WP_270140156.1 multidrug efflux RND transporter permease subunit AcrB -
OH773_RS16665 (OH773_16665) 3605577..3605951 + 375 WP_034458068.1 Hha toxicity modulator TomB Antitoxin
OH773_RS16670 (OH773_16670) 3605981..3606199 + 219 WP_121265420.1 HHA domain-containing protein Toxin
OH773_RS16675 (OH773_16675) 3606370..3606936 + 567 WP_270140161.1 maltose O-acetyltransferase -
OH773_RS16680 (OH773_16680) 3607039..3607497 + 459 WP_270140163.1 YlaC family protein -
OH773_RS16685 (OH773_16685) 3607538..3607678 - 141 WP_034458060.1 type B 50S ribosomal protein L36 -
OH773_RS16690 (OH773_16690) 3607996..3609033 + 1038 WP_270140167.1 isopenicillin N synthase family oxygenase -
OH773_RS16695 (OH773_16695) 3609052..3609861 + 810 WP_270140169.1 MetQ/NlpA family ABC transporter substrate-binding protein -
OH773_RS16700 (OH773_16700) 3609858..3610649 + 792 WP_270140172.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8624.06 Da        Isoelectric Point: 9.4828

>T263094 WP_121265420.1 NZ_CP110080:3605981-3606199 [Buttiauxella sp. WJP83]
MTTKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14512.27 Da        Isoelectric Point: 4.7295

>AT263094 WP_034458068.1 NZ_CP110080:3605577-3605951 [Buttiauxella sp. WJP83]
MDEYSPKRHDIAQLKFLCENLYHDCLTNLGESNHGWVNDPTSAINLQLNELIEHIAAFALNYKIKYDDESKLIEQIDEYL
DDTFMLFSNYGINAQDLQKWRKSGNRLFRCFVTESRANPVSLSF

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7HUH8

References