Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2494396..2495030 Replicon chromosome
Accession NZ_CP110080
Organism Buttiauxella sp. WJP83

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag OH773_RS11560 Protein ID WP_270138761.1
Coordinates 2494396..2494671 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag OH773_RS11565 Protein ID WP_270145825.1
Coordinates 2494683..2495030 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OH773_RS11535 (OH773_11535) 2489725..2490318 - 594 WP_270145820.1 tellurite resistance methyltransferase TehB -
OH773_RS11540 (OH773_11540) 2490314..2491303 - 990 WP_270138754.1 dicarboxylate transporter/tellurite-resistance protein TehA -
OH773_RS11545 (OH773_11545) 2491424..2492353 + 930 WP_270138756.1 YdcK family protein -
OH773_RS11550 (OH773_11550) 2492377..2492889 - 513 WP_270145823.1 50S ribosomal protein L7/L12-serine acetyltransferase -
OH773_RS11555 (OH773_11555) 2493123..2494280 + 1158 WP_270138759.1 FAD-dependent urate hydroxylase HpxO -
OH773_RS11560 (OH773_11560) 2494396..2494671 + 276 WP_270138761.1 type II toxin-antitoxin system HicA family toxin Toxin
OH773_RS11565 (OH773_11565) 2494683..2495030 + 348 WP_270145825.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
OH773_RS11570 (OH773_11570) 2495067..2496722 - 1656 WP_270138763.1 glucan biosynthesis protein -
OH773_RS11575 (OH773_11575) 2496978..2497754 - 777 WP_270138765.1 ABC transporter substrate-binding protein -
OH773_RS11580 (OH773_11580) 2497767..2498936 - 1170 WP_270138767.1 pyridoxal phosphate-dependent aminotransferase -
OH773_RS11585 (OH773_11585) 2499059..2499919 + 861 WP_270138769.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-77)

Antitoxin

Uncharacterised protein family HicB

(56-108)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10316.84 Da        Isoelectric Point: 10.4734

>T263092 WP_270138761.1 NZ_CP110080:2494396-2494671 [Buttiauxella sp. WJP83]
MGYDKDFLRNKHQGTLKQIFAKPTSTSIRWQDVEMLIIALNGEVRSGKGSRVRFLLKGSIAHFHRPHPSPETDKGAIVNL
QEWFESIGVTP

Download         Length: 276 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12924.06 Da        Isoelectric Point: 4.9009

>AT263092 WP_270145825.1 NZ_CP110080:2494683-2495030 [Buttiauxella sp. WJP83]
MIPNTMVICGQPALITWVPEIGLFRGKFLGLSGYCDFVADSAKGLMAEGELSLKEYLDDCKTSGIDPYEREEKIKTFTLR
YPESFGERLAIAAAEQRMSVNSYIVEMLSKQMKLK

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References