Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 61370..61866 Replicon plasmid pBE5_1
Accession NZ_CP110075
Organism Enterococcus faecalis strain BE5

Toxin (Protein)


Gene name relE Uniprot ID R3GZA4
Locus tag OLM06_RS14540 Protein ID WP_002358470.1
Coordinates 61370..61639 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R3JPM7
Locus tag OLM06_RS14545 Protein ID WP_002413218.1
Coordinates 61639..61866 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM06_RS14535 (OLM06_14515) 59723..61303 - 1581 WP_010821329.1 DUF3991 domain-containing protein -
OLM06_RS14540 (OLM06_14520) 61370..61639 - 270 WP_002358470.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OLM06_RS14545 (OLM06_14525) 61639..61866 - 228 WP_002413218.1 DUF6290 family protein Antitoxin
OLM06_RS14550 (OLM06_14530) 61926..63161 - 1236 WP_033780699.1 MobP2 family relaxase -
OLM06_RS14555 (OLM06_14535) 63164..63721 - 558 WP_002358242.1 hypothetical protein -
OLM06_RS14560 (OLM06_14540) 63714..63974 - 261 WP_010707423.1 ribbon-helix-helix protein, CopG family -
OLM06_RS14565 (OLM06_14545) 64354..65178 - 825 WP_048955619.1 hypothetical protein -
OLM06_RS14570 (OLM06_14550) 65193..65717 - 525 WP_002358238.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - asa1 1..74135 74135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10610.17 Da        Isoelectric Point: 10.5395

>T263081 WP_002358470.1 NZ_CP110075:c61639-61370 [Enterococcus faecalis]
MSYRLEFTPDVKKQLKKMDKYQATLLTRWLYRNIDGTANPREHGKALSANRAGQWRYRIGNYRVIVEIEDERLVVTAIQV
GHRRNVYDK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8785.90 Da        Isoelectric Point: 4.0179

>AT263081 WP_002413218.1 NZ_CP110075:c61866-61639 [Enterococcus faecalis]
MAMITVRVSDEEKEWLSYMAEFFGVTLSDLLKSYSMEQLEDEYDKQTAEIAHKRWIEQGKETISMDEILNEFGGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3GZA4

Antitoxin

Source ID Structure
AlphaFold DB R3JPM7

References