263056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 412619..413201 Replicon chromosome
Accession NZ_CP110074
Organism Enterococcus faecalis strain BE5

Toxin (Protein)


Gene name zeta Uniprot ID A0A0M2AE74
Locus tag OLM06_RS02080 Protein ID WP_002355414.1
Coordinates 412893..413201 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag OLM06_RS02075 Protein ID WP_002326825.1
Coordinates 412619..412891 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLM06_RS02045 (407900) 407900..408628 - 729 WP_002355404.1 GntR family transcriptional regulator -
OLM06_RS02050 (408805) 408805..409731 + 927 WP_002355406.1 hypothetical protein -
OLM06_RS02055 (409748) 409748..411031 + 1284 WP_002363033.1 PTS sugar transporter subunit IIC -
OLM06_RS02060 (411223) 411223..411345 + 123 Protein_382 topoisomerase -
OLM06_RS02065 (411420) 411420..412316 + 897 WP_002363034.1 ParA family protein -
OLM06_RS02070 (412393) 412393..412602 + 210 WP_002363035.1 peptide-binding protein -
OLM06_RS02075 (412619) 412619..412891 + 273 WP_002326825.1 antitoxin Antitoxin
OLM06_RS02080 (412893) 412893..413201 + 309 WP_002355414.1 zeta toxin family protein Toxin
OLM06_RS02085 (413281) 413281..413688 - 408 WP_224571294.1 tyrosine-type recombinase/integrase -
OLM06_RS02090 (413755) 413755..414255 - 501 WP_002363039.1 HAD family hydrolase -
OLM06_RS02095 (414260) 414260..415027 - 768 WP_002355416.1 DeoR/GlpR family DNA-binding transcription regulator -
OLM06_RS02100 (415514) 415514..415939 + 426 WP_002355418.1 galactose-6-phosphate isomerase subunit LacA -
OLM06_RS02105 (415956) 415956..416471 + 516 WP_002345825.1 galactose-6-phosphate isomerase subunit LacB -
OLM06_RS02110 (416482) 416482..417414 + 933 WP_264563359.1 tagatose-6-phosphate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ClpL bsh / esp 380432..469769 89337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-99)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11525.91 Da        Isoelectric Point: 5.7251

>T263056 WP_002355414.1 NZ_CP110074:412893-413201 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKHATSYSNQLVKLN

Download         Length: 309 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT263056 WP_002326825.1 NZ_CP110074:412619-412891 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2AE74

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References