Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1545670..1546807 Replicon chromosome
Accession NZ_CP110072
Organism Enterococcus faecalis strain BE7

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OLL88_RS07450 Protein ID WP_002401483.1
Coordinates 1545944..1546807 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag OLL88_RS07445 Protein ID WP_000301765.1
Coordinates 1545670..1545942 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL88_RS07415 (1542073) 1542073..1543599 + 1527 WP_025191980.1 type IA DNA topoisomerase -
OLL88_RS07420 (1543719) 1543719..1543841 + 123 Protein_1458 peptide-binding protein -
OLL88_RS07425 (1543910) 1543910..1544005 + 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
OLL88_RS07430 (1544130) 1544130..1544867 + 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
OLL88_RS07435 (1545037) 1545037..1545297 + 261 Protein_1461 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
OLL88_RS07440 (1545438) 1545438..1545653 + 216 WP_002295735.1 peptide-binding protein -
OLL88_RS07445 (1545670) 1545670..1545942 + 273 WP_000301765.1 antitoxin Antitoxin
OLL88_RS07450 (1545944) 1545944..1546807 + 864 WP_002401483.1 zeta toxin family protein Toxin
OLL88_RS07455 (1547248) 1547248..1547565 + 318 WP_002333463.1 hypothetical protein -
OLL88_RS07460 (1547585) 1547585..1547674 + 90 Protein_1466 DnaJ domain-containing protein -
OLL88_RS07465 (1547749) 1547749..1548429 + 681 WP_010710189.1 IS6-like element IS1216 family transposase -
OLL88_RS07470 (1548411) 1548411..1548647 + 237 WP_264554385.1 ketopantoate reductase C-terminal domain-containing protein -
OLL88_RS07475 (1548923) 1548923..1549774 + 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
OLL88_RS07480 (1549776) 1549776..1550543 + 768 WP_002357481.1 ribonuclease HII -
OLL88_RS07485 (1550604) 1550604..1551467 + 864 WP_002382350.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia - 1504306..1541001 36695
- inside IScluster/Tn str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia / erm(B) - 1521621..1548429 26808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T263050 WP_002401483.1 NZ_CP110072:1545944-1546807 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT263050 WP_000301765.1 NZ_CP110072:1545670-1545942 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3Q8X
PDB 1GVN
AlphaFold DB A0A829F0A3

References