Detailed information of TA system TA026305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2760925..2761604
• Replicon: chromosome
• Accession: NC_017162
• Organism: Acinetobacter baumannii 1656-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: ABK1_RS13340
• Protein ID: WP_000838146.1
• Coordinates: 2761422..2761604 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: ABK1_RS13335
• Protein ID: WP_000966688.1
• Coordinates: 2760925..2761329 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABK1_RS13325	2759881..2760144	-	264	WP_001275792.1	hypothetical protein	-
ABK1_RS13330	2760146..2760826	-	681	WP_000721572.1	hypothetical protein	-
ABK1_RS13335	2760925..2761329	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ABK1_RS13340	2761422..2761604	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
ABK1_RS13345	2761930..2762445	-	516	WP_001185586.1	hypothetical protein	-
ABK1_RS13350	2762515..2763432	-	918	WP_000094278.1	hypothetical protein	-
ABK1_RS13355	2763485..2764789	-	1305	WP_000002401.1	pyocin knob domain-containing protein	-
ABK1_RS13360	2764789..2765139	-	351	WP_000064572.1	hypothetical protein	-
ABK1_RS13365	2765236..2765454	-	219	WP_001277691.1	hypothetical protein	-
ABK1_RS13370	2765456..2765899	-	444	WP_002039534.1	hypothetical protein	-
ABK1_RS13375	2765856..2766224	-	369	WP_000539744.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2744409..2785440	41031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T26305 WP_000838146.1 NC_017162:c2761604-2761422 [Acinetobacter baumannii 1656-2]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T26305 NC_017162:c2761604-2761422 [Acinetobacter baumannii 1656-2]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT26305 WP_000966688.1 NC_017162:c2761329-2760925 [Acinetobacter baumannii 1656-2]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT26305 NC_017162:c2761329-2760925 [Acinetobacter baumannii 1656-2]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6