Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1537084..1538192 Replicon chromosome
Accession NZ_CP110072
Organism Enterococcus faecalis strain BE7

Toxin (Protein)


Gene name MNTss Uniprot ID A0A193AUR0
Locus tag OLL88_RS07390 Protein ID WP_002378351.1
Coordinates 1537323..1538192 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OLL88_RS07385 Protein ID WP_000205227.1
Coordinates 1537084..1537308 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL88_RS07365 (1532715) 1532715..1534199 + 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
OLL88_RS07370 (1534253) 1534253..1535056 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
OLL88_RS07375 (1535365) 1535365..1536666 - 1302 Protein_1449 ISL3 family transposase -
OLL88_RS07380 (1536855) 1536855..1536941 + 87 Protein_1450 site-specific recombinase -
OLL88_RS07385 (1537084) 1537084..1537308 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
OLL88_RS07390 (1537323) 1537323..1538192 + 870 WP_002378351.1 nucleotidyltransferase domain-containing protein Toxin
OLL88_RS07395 (1538173) 1538173..1538907 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OLL88_RS07400 (1538940) 1538940..1539803 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OLL88_RS07405 (1539973) 1539973..1540374 + 402 WP_002401582.1 phosphoribosyltransferase family protein -
OLL88_RS07410 (1540602) 1540602..1541921 + 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia - 1504306..1541001 36695
- inside IScluster/Tn str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia / erm(B) - 1521621..1548429 26808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32912.50 Da        Isoelectric Point: 4.7903

>T263049 WP_002378351.1 NZ_CP110072:1537323-1538192 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT263049 WP_000205227.1 NZ_CP110072:1537084-1537308 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193AUR0

Antitoxin

Source ID Structure

References