Detailed information of TA system TA026304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1644641..1645320
• Replicon: chromosome
• Accession: NC_017162
• Organism: Acinetobacter baumannii 1656-2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: ABK1_RS08025
• Protein ID: WP_000838146.1
• Coordinates: 1644641..1644823 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: ABK1_RS08030
• Protein ID: WP_000966688.1
• Coordinates: 1644916..1645320 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABK1_RS07990	1639661..1640104	+	444	WP_002016455.1	hypothetical protein	-
ABK1_RS07995	1640106..1640324	+	219	WP_001277696.1	hypothetical protein	-
ABK1_RS08000	1640433..1640954	+	522	WP_000749909.1	SH3 domain-containing protein	-
ABK1_RS08005	1641051..1641404	+	354	WP_000064593.1	hypothetical protein	-
ABK1_RS08010	1641404..1642759	+	1356	WP_000002415.1	hypothetical protein	-
ABK1_RS08015	1642812..1643729	+	918	WP_000094253.1	hypothetical protein	-
ABK1_RS08020	1643800..1644315	+	516	WP_024616020.1	hypothetical protein	-
ABK1_RS08025	1644641..1644823	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
ABK1_RS08030	1644916..1645320	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
ABK1_RS19695	1645419..1645595	+	177	WP_014466185.1	hypothetical protein	-
ABK1_RS08035	1645604..1645927	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
ABK1_RS08040	1645959..1646753	+	795	WP_000720608.1	hypothetical protein	-
ABK1_RS08045	1646802..1647041	-	240	WP_000763623.1	Arc family DNA-binding protein	-
ABK1_RS19700	1647164..1647319	+	156	WP_001103649.1	Arc family DNA-binding protein	-
ABK1_RS08050	1647316..1648308	+	993	WP_000835645.1	KilA-N domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1610444..1662416	51972

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T26304 WP_000838146.1 NC_017162:1644641-1644823 [Acinetobacter baumannii 1656-2]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T26304 NC_017162:1644641-1644823 [Acinetobacter baumannii 1656-2]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT26304 WP_000966688.1 NC_017162:1644916-1645320 [Acinetobacter baumannii 1656-2]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT26304 NC_017162:1644916-1645320 [Acinetobacter baumannii 1656-2]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6