263035

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta-epsilon
Location 1502386..1503523 Replicon chromosome
Accession NZ_CP110071
Organism Enterococcus faecalis strain BE8

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag OLL94_RS07150 Protein ID WP_002401483.1
Coordinates 1502660..1503523 (+) Length 288 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID R2XCR7
Locus tag OLL94_RS07145 Protein ID WP_000301765.1
Coordinates 1502386..1502658 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL94_RS07115 (1498789) 1498789..1500315 + 1527 WP_025191980.1 type IA DNA topoisomerase -
OLL94_RS07120 (1500435) 1500435..1500557 + 123 Protein_1400 peptide-binding protein -
OLL94_RS07125 (1500626) 1500626..1500721 + 96 WP_001809736.1 23S rRNA methyltransferase attenuation leader peptide -
OLL94_RS07130 (1500846) 1500846..1501583 + 738 WP_002292226.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
OLL94_RS07135 (1501753) 1501753..1502013 + 261 Protein_1403 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
OLL94_RS07140 (1502154) 1502154..1502369 + 216 WP_002295735.1 peptide-binding protein -
OLL94_RS07145 (1502386) 1502386..1502658 + 273 WP_000301765.1 antitoxin Antitoxin
OLL94_RS07150 (1502660) 1502660..1503523 + 864 WP_002401483.1 zeta toxin family protein Toxin
OLL94_RS07155 (1503964) 1503964..1504281 + 318 WP_002333463.1 hypothetical protein -
OLL94_RS07160 (1504301) 1504301..1504390 + 90 Protein_1408 DnaJ domain-containing protein -
OLL94_RS07165 (1504465) 1504465..1505145 + 681 WP_010710189.1 IS6-like element IS1216 family transposase -
OLL94_RS07170 (1505127) 1505127..1505363 + 237 WP_264554385.1 ketopantoate reductase C-terminal domain-containing protein -
OLL94_RS07175 (1505639) 1505639..1506490 + 852 WP_002357480.1 ribosome biogenesis GTPase YlqF -
OLL94_RS07180 (1506492) 1506492..1507259 + 768 WP_002357481.1 ribonuclease HII -
OLL94_RS07185 (1507320) 1507320..1508183 + 864 WP_002382350.1 DNA-processing protein DprA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia - 1461022..1497717 36695
- inside IScluster/Tn str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia / erm(B) - 1478337..1505145 26808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-213)

Antitoxin

Bacterial epsilon antitoxin

(2-90)


Sequences

Toxin        


Download         Length: 288 a.a.        Molecular weight: 32486.06 Da        Isoelectric Point: 6.9965

>T263035 WP_002401483.1 NZ_CP110071:1502660-1503523 [Enterococcus faecalis]
MANIVNFTDKQFENRLNDNLEELIQGKKAVESPTAFLLGGQPGSGKTSLRSAILEETQGNVIVIDNDTFKQQHPNFDELA
KLYEKDVVKHVTPYSNRMTEAIISRLSDQGYNLVIEGTGRTTDVPIQTATMLQAKGYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSRLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMLQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGL

Download         Length: 864 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10721.25 Da        Isoelectric Point: 6.4676

>AT263035 WP_000301765.1 NZ_CP110071:1502386-1502658 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELNKNDSQLLEVNLLNQLKLAKRVNLFDYSLEELQAVHEYWRSMNRYS
KQVLNKEKVA

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829F0A3

References