Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1493800..1494908 Replicon chromosome
Accession NZ_CP110071
Organism Enterococcus faecalis strain BE8

Toxin (Protein)


Gene name MNTss Uniprot ID A0A193AUR0
Locus tag OLL94_RS07090 Protein ID WP_002378351.1
Coordinates 1494039..1494908 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag OLL94_RS07085 Protein ID WP_000205227.1
Coordinates 1493800..1494024 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OLL94_RS07065 (1489431) 1489431..1490915 + 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
OLL94_RS07070 (1490969) 1490969..1491772 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
OLL94_RS07075 (1492081) 1492081..1493382 - 1302 Protein_1391 ISL3 family transposase -
OLL94_RS07080 (1493571) 1493571..1493657 + 87 Protein_1392 site-specific recombinase -
OLL94_RS07085 (1493800) 1493800..1494024 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
OLL94_RS07090 (1494039) 1494039..1494908 + 870 WP_002378351.1 nucleotidyltransferase domain-containing protein Toxin
OLL94_RS07095 (1494889) 1494889..1495623 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
OLL94_RS07100 (1495656) 1495656..1496519 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
OLL94_RS07105 (1496689) 1496689..1497090 + 402 WP_002401582.1 phosphoribosyltransferase family protein -
OLL94_RS07110 (1497318) 1497318..1498637 + 1320 WP_002338419.1 IS1380-like element ISSsu5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia - 1461022..1497717 36695
- inside IScluster/Tn str / cat / aph(3')-III / lsa(E) / lnu(B) / ant(6)-Ia / erm(B) - 1478337..1505145 26808


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32912.50 Da        Isoelectric Point: 4.7903

>T263034 WP_002378351.1 NZ_CP110071:1494039-1494908 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYNEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT263034 WP_000205227.1 NZ_CP110071:1493800-1494024 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A193AUR0

Antitoxin

Source ID Structure

References